Where splicing joins chromatin
نویسندگان
چکیده
منابع مشابه
Chromatin density and splicing destiny: on the cross-talk between chromatin structure and splicing.
How are short exonic sequences recognized within the vast intronic oceans in which they reside? Despite decades of research, this remains one of the most fundamental, yet enigmatic, questions in the field of pre-mRNA splicing research. For many years, studies aiming to shed light on this process were focused at the RNA level, characterizing the manner by which splicing factors and auxiliary pro...
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Much remains unknown concerning the mechanism by which the splicing machinery pinpoints short exons within intronic sequences and how splicing factors are directed to their pre-mRNA targets. One probable explanation lies in differences in chromatin organization between exons and introns. Proteomic, co-immunoprecipitation, and sedimentation analyses described here indicate that SF3B1, an essenti...
متن کاملFaster Joins , Self - Joins and
We propose a new algorithm, called Stripe-join, for performing a join given a join index. Stripe-join is inspired by an algorithm called \Jive-join" developed by Li and Ross. Stripe-join makes a single sequential pass through each input relation, in addition to one pass through the join index and two passes through a set of temporary les that contain tuple identiiers but no input tuples. Stripe...
متن کاملFrom chromatin to splicing: RNA-processing as a total artwork.
RNA plays a central role in the determination of the phenotype of the cell. The molecular mechanisms involved in primary RNA synthesis and subsequent post-processing are not completely understood, but there is increasing evidence that they are more tightly coupled than previously expected. The analyses by a number of groups of recently published genome wide maps of chromatin structure have furt...
متن کاملSudemycin E influences alternative splicing and changes chromatin modifications
Sudemycin E is an analog of the pre-messenger RNA splicing modulator FR901464 and its derivative spliceostatin A. Sudemycin E causes the death of cancer cells through an unknown mechanism. We found that similar to spliceostatin A, sudemycin E binds to the U2 small nuclear ribonucleoprotein (snRNP) component SF3B1. Native chromatin immunoprecipitations showed that U2 snRNPs physically interact w...
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ژورنال
عنوان ژورنال: Nucleus
سال: 2011
ISSN: 1949-1034,1949-1042
DOI: 10.4161/nucl.2.3.15876